By admin 
Here are some tablet compression interview questions and answers:
Q1: What is tablet compression, and how does it work?
A1: Tablet compression is a process where a powder or granule mixture is compressed into a solid tablet using a machine. The mixture is fed into a die, and a punch compresses it into a tablet shape.
Q2: What are the critical parameters in tablet compression?
A2: Critical parameters include compression force, speed, dwell time, and punch penetration depth. These parameters affect tablet quality, weight, and hardness.
Q3: How do you ensure uniform tablet weight and hardness?
A3: By controlling the compression force, speed, and dwell time, and ensuring consistent powder flow and die filling.
Q4: What is the purpose of a die and punch in tablet compression?
A4: The die shapes the tablet, while the punch compresses the powder mixture into the die.
Q5: How do you troubleshoot common issues like tablet sticking or picking?
A5: By adjusting compression force, speed, or dwell time, or changing the punch or die design.
Q6: What are the advantages and disadvantages of wet granulation vs. dry granulation?
A6: Wet granulation offers better powder flow and compressibility but requires drying. Dry granulation is faster and cheaper but may produce weaker tablets.
Q7: How do you optimize tablet compression parameters for a new product?
A7: By conducting experiments to determine the optimal compression force, speed, and dwell time, and testing different formulations.
Q8: What is the role of compression force and speed in tablet compression?
A8: Compression force determines tablet hardness, while speed affects tablet weight and quality.
Q9: How do you ensure tablet quality and consistency during large-scale production?
A9: By monitoring critical parameters, conducting regular quality control checks, and maintaining equipment calibration.
Q10: What are common issues in tablet compression, and how do you address them?
A10: Issues include capping, lamination, and sticking. Address them by adjusting compression parameters, punch or die design, or material properties.
Remember to provide specific examples from your experience and explain the underlying principles and concepts.